u937 cells — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2S1040	Jolkinolide B		ERK , IL Receptor , BCL , p38 MAPK , TNF , NF-κB , Akt , Caspase , PI3K , JAK , JNK , STAT , mTOR
	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis.
TN2054	Periplocymarin		Calcium Channel
	Periplocymarin is a cardiac glycoside with anticancer potential isolated from Periploca sepium and Periploca graeca.		Calcium Channel
T5821	BC-1215		Others , Ligand for E3 Ligase
	BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release).		Others , Ligand for E3 Ligase
T5622	BAY-218	AHR antagonist 1	AhR , Aryl Hydrocarbon Receptor
	BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.		AhR , Aryl Hydrocarbon Receptor
T8531	M-3M3FBS		Apoptosis , Phospholipase
	m-3M3FBS is a phospholipase C (PLC) activator.		Apoptosis , Phospholipase
T63055	RIPK1-IN-9		RIP kinase
	RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respectively.		RIP kinase
T77697	BML-278	BML278,BML 278	Sirtuin , Histone Methyltransferase
	BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind...		Sirtuin , Histone Methyltransferase
T5S1923	Schisandrin C	Schizandrin-C,Wuweizisu-C	Apoptosis , Others , Virus Protease
	Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.		Apoptosis , Others , Virus Protease
T78156	MC4033		Apoptosis
	MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1]. Additionally, treatment with MC4033 at concentrations of 25, 50, 100, and 200 µM f...		Apoptosis
T3229	Cytochalasin D		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head dec...		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
T4057	Hoechst 33258 trihydrochloride	Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258	Parasite
	Hoechst 33258 trihydrochloride (Bisbenzimide) is a benzimidazole anti-filarial agent. it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication. it also interfe...		Parasite
T63854	Cathepsin C-IN-3
	Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).
T10050	1alpha-Hydroxy VD4	1α-Hydroxy vitamin D4	Others
	1alpha-Hydroxy VD4 can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU, and P31/FUJ cells.		Others
T62659	Cathepsin C-IN-4
	Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).
T36319	C6 L-erythro Ceramide (d18:1/6:0)	C6 L-erythro Ceramide (d18:1/6:0)
	C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide...
TN1211	2-Hydroxy-3-methylanthraquinone		ERK , p38 MAPK , Caspase
	2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activation mediated apoptotic induction.		ERK , p38 MAPK , Caspase
T62499	RIPK1-IN-14
	RIPK1-IN-14 (Compound 41) is a potent inhibitor of RIPK1 (IC50: 92 nM).RIPK1-IN-14 has a significant anti-necrotic apoptotic effect in a model of necrotic apoptosis in U937 cells.
T26775	Bepafant	WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170
	Bepafant is a platelet activating factor (PAF) antagonist. Bepafant may produce significant anti-inflammatory effects. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1...
T36322	C8 D-threo Ceramide (d18:1/8:0)	C8 D-threo Ceramide (d18:1/8:0)
	C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently th...